Lichtman M A, Miller D R, Cohen I & Waterhouse C. Reduced red cell glycolysis, 2, 3-diphosphoglycerate and adenosine triphosphate concentration, and increased hemoglobin-oxygen affinity caused by hypophosphalemia. Ann. Intern. Med. 74:562-8, 1971

This paper described the curtailment of red-cell glycolysis, decreased red-cell organic phosphates. and increased hemoglobin-oxygen affinity that resulted from severe hypophosphatemia, which occurred during the use of parenteral nutrition The observations suggested that decreased concentrations of red-cell 2,3.diphosphoglycerate impaired red-cell function and that decreased red. cell adenosine triphosphate threatened red-cell survival. Both effects decrease oxygen transport. (The SC!® indicates that this paper has been cited in over 165 publications since 1971